From: Ricin Subject: Re: hydrocodone solubility Date: 1997/10/02 Newsgroups: alt.drugs.chemistry,alt.drugs.hard according to the merck index ( 12 ed ) , 1 gm of hydrocodone is soluble in 16 ml H2O. -- ==================================================================== From: arno Subject: Re: hydrocodone solubility Date: 1997/10/11 Newsgroups: alt.drugs.chemistry Samson wrote: > > In article , > Jeffrey Z Rothstein wrote: > > > > > Dissolve the HC in a very small amount of warm water. Cool it down in > > > > the freezer for 10 minutes. Strain through a paper towel atop a very > > > > small strainer. The tylenol will stay in the paper towel. Drink it > APAP is not soluble in cold water, so the filtered, cooled solution will > either be hydrocodone juice or just plain water. You can measure your > yield, of course: weigh the pills beforehand, then weigh the precipitate > (after drying it, of course). Unfortunately this won't work. Some aceataminophen will also dissolve in the water, and this will mess up the situation. The solubility of acetaminophen (and acetylsalicylic acid and codeine) given in the codeine FAQ (http://www.paranoia.com/drugs/opiates/FAQ-Codeine) are: Solubility (31C water) Solubility (21C water) Aspirin 1g / 100 ml 1g / 300ml Acetaminophen 1g / 70 ml 1g / 150 ml Codeine 1g / 2.3 ml 1g / 0.7 ml Phosphate Considering the amout of water needed to extract most of the desired substance, there will be plenty of acetaminiphen in the solution (from the point of view of weight). Also, some tablets contain other water soluble additives without medicinal action. Therefore, though very vague, it's prorbaly more accurate to estimate the amount of hydrocodone from the subjective effect on ingestion. A different, but interesting thing to see in the figures from the faq is that codeine dissolves better in cold than in warm water. I don't know if the same applies to hydorcodone but anyway, to solubility in cold water is more than sufficient for any extraction. In the faq, it is recommended to use hot water for dissolving the tablets but a better method would be to simply make sure that the tablets are finely ground and use water of room temperature for extraction. If no mortar is available, another easy method to do this is by first allowing the tablets to fall apart in a sufficient amount of cold water first and then pouring them back and forth for a while between two large enough beakers. always pouring them from as high as possible without spurting (creating a waterfall-effect that is very effective). Actually, in most tablets, at least in Europe, hot water would only mess up the situation, causing certain materials in the tablet to swell and hindering the filtering process. Also, dissolved paracetamol (or, in some tablets spirin) binds water in the process of recristallisation and is difficult to separate later without lowering the total yield. So I don't know the composition of Vicodin, but would think it is a similar situation. However, in a cold extraction, it is necessary to do the fine grinding or the waterfall or similar method. The reason is that if they are avoided and the tablets are only allowed to fall apart, then filtered, the yield will be significantly lower. ==================================================================== From: arno Subject: Re: hydrocodone solubility Date: 1997/10/11 Newsgroups: alt.drugs.chemistry [...] >Never tried the process myself. I went through the APAP OD thing, and >though my liver is fine, it was such a pain in the ass that I don't >consider the risk worth taking. Even if imagining the risk involves >denying the laws of thermodynamics. You could check out the risk yourself in a non-wasteful experiment by doing the same extraction method with pure APAP tablets. Either weigh the precipitate or, even easier, boil away the water and see if a significant amount of material is left over. If not, the process is safe. ==================================================================== From: "XCOM" Subject: Re: hydrocodone solubility Date: 1997/10/13 Newsgroups: alt.drugs.hard [...] > another easy method to do this is by first allowing the tablets to fall > apart in a sufficient amount of cold water first and then pouring them back and > forth for a while between two large enough beakers. always pouring them > from as high as possible without spurting (creating a waterfall-effect > that is very effective). I have to agree with this. I also crush up the pills and in a small measureing glass with a hard wooden cosmetic brush( my girlfriends, I can't find a mortar and pestle, wish I could. I use warm water to help the fillers and stuff dissolve completely, even though they are ground. Then I put them in the freezer and when you see it seperate with the fillers and acet. on the bottom of the glass, I have started mixing it to be sure it is seperated completely, then leave it set some more till it is completly seperated. Usually about ten minutes. Then I pour off the top solution (clear) into the filtration device. While it's filtering I add about another 60ml of water (tap temperature) to the left over filller and acet. and stir and place back in thre freezer. This gets any remaining Hydrocodone out of the filler/acet.. After I've done all the filtering and junk (I use coffee filters) I add some sugar and Strawberry Quick (or punch or whatever you Have) I have also heard adding lemon juice helps it convert to the brain faster or helps more of it to be used than Digested, but can't verify this for a fact. > Actually, in most tablets, at least in Europe, hot water would only > mess up the situation, causing certain materials in the tablet to swell and > hindering the filtering process. Also, dissolved paracetamol (or, in that is why I say do not pour the whole thing into the filter. Just the solution seperated on top. The "swollen" fillers and such can be cold water extracted and poured off the top again, this speeds up the filtration as all the solids don't clog the filter. [...]