From: Samson 
Subject: Re: hydrocodone question
Date: 18 Feb 2000
Newsgroups: alt.drugs.hard

>(JPET, 281:103-8) ... is actually online in full,
(though I didn't know this two years ago and plunked down
the 60 cents for photocopies). It's at

http://jpet.aspetjournals.org/cgi/content/full/281/1/103

>(Drug Metab Dispos, 24:761-4)

... you'll have to get from a library. ASPET also
publishes Drug Metabolism and Disposition, but the full-
text archive only goes back to Vol. 25. You can
get it at a med library, or just look at the abstract
at PubMed http://www.ncbi.nlm.nih.gov/PubMed/medline.html
or ASPET's site http://www.aspetjournals.org

> BTW, 'demthylated' oxymorphone is a urine byproduct of
> oxycodone ingestion. Is this active? I am considering a urine
> extraction.

Is what active -- oxymorphone or 'demethylated' oxymorphone
(i.e., noroxymorphone)? They're both active, the former more
than the latter. Oxymorphone is produced in such small
quantities from oxycodone (through *O*-demethylation, not
to be confused with *N*-demethylation) that early studies
weren't even able to detect it.

I  don't think these are online, but you can plug these
articles into the Citation Matcher at PubMed for more
on the oxycodone-oxymorphone story (I think the abstracts
are there at least):

--Poyhia, R. et al. Br J Clin Pharmacol 1992, vol 33, pp 617-621
(p. 619: "Plasma concentrations of oxymorphone were below the limit of
the assay.")

--Kaiko, R.F. et al. Clin Pharmacol Ther 1996, vol 59, pp 52-61
(p.60: "...plasma concentrations of oxymorphone remained very low,
if measurable at all, after oxycodone administration, and
pharmacodynamic effects were signficantly correlated with
oxycodone, not oxymorphone." 

In the latter, effects were actually *negatively* correlated with 
oxymorphone concentration, probably because higher oxymorphone conc. 
resulted from faster elimination of oxycodone.

I also recommend
http://www.dml.georgetown.edu/depts/pharmacology/davetab.html
again, for all your CYP450 information needs.


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