From: durtro@aol.com (Durtro)
Subject: serving suggestions
Date: 1997/08/12
Newsgroups: alt.drugs.hard

we are all familiar with:

MAY CAUSE DROWSINESS.  alcohol may intensify this effect.  use care when
operating a car or dangerous machinery.

from POZ magazine, september 1997-p. 90 "Pulp Fiction and Facts"

"grapefruit juice lowers the intestinal breakdown of many drugs by
inhibiting the intestinal enzyme (CYP3A4) involved in their metabolism. 
The effect on most drugs is to put a higher concentration in the
bloodstream.  For example,  researchers at Hoffmann-La Roche found that
drinking 150 ml (around 5/8 of a cup) of reconstituted frozen grapefruit
juice, both when saquinavir is taken and again in an hour after the
dose, leads to an average 50 percent increase in blood levels of the
drug.  Curiously, however, that same glass of grapefruit juice appears
to decrease blood levels of Crixivan (indinavir), possibly lowering it's
effectiveness and increasing the chance of the development of a
resistance.

(for the uninitiated, Crixivan and Saquinavir are antiHIV drugs...but
read on)

benzodiazepenes are mentioned as being increased as a result of
grapefruit juice.  different brands and lots of grapefruit juice will
yield different results.  the article continues:

"it's quite possible that grapefruit juice could increase the levels of
many of these enough to create a serious toxicity.  Caveat emptor."

just funny, how i always drink grapefruit juice.  sure, it tastes nasty,
but the mind of a junky knows things the body tells it, whether or not
these things are verbalized.  damn, grapefruit juice, all these years.
better watch it now, that i am on antivirals.  but woo woo i thought
grapefruit  kicked in those xanax.  wubba wubba gub.

like they say, caveat emptor.


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