From: (Samson) Newsgroups: alt.drugs.hard Subject: Answer for someone credulous (was Re: Question from someone new Date: 5 Nov 1998 23:47:51 GMT In article <71sc98$6ia$1@nnrp1.dejanews.com>, witchdoctor2000@my-dejanews.com wrote: [...] > Then Samson piped up to point out that Martin Booth's > mention on p. 97 of his 1996 book titled Opium: A History, > that "one sugggests [dolophine] was named after Adolph > Hitler" is analogous to suggesting (who says this, > Samson?) that LSD can be made from Foster's Beer. > > Again. Who says "that LSD can be made from Foster's Beer"? > > And. OK Samson, where is your (published) source for > the claim that dolophine was *not* named after Adolph H.? (1) Scott, C. & Chen, K.: "The action of 1,1-diphenyl-1- (dimethylisopropyl)-butanone-2, a potent analgesic agent," _J. Pharmacol Exp Ther_, 87:63 (May 1946): [Research conducted at Lilly Research Laboratories, Indianapolis] "Following the Allied victory of World War II, knowledge of additional related compounds [to pethidine], prepared by German chemists, bacame available through a team headed by Ervin C. Kleiderer, Technical Industrial Intelligence Committee under the Foreign Economic Administration, U.S Department of State. A report by the Committee has been published by the U.S. Department of Commerce. Of the many compounds disclosed, 1,1-diphenyl-1-(dimethylisopropyl)- butanone-2 appeared to be outstanding. This compound bears the German serial number 10820. Since detals of pharmacological work were not available in the above- mentioned report, we undertook an investigation of the actions of 10820." This was the first (known, published) detailed investigation of the action of methadone. The year was 1946. The cash was put up by Lilly. (2) Isbell, H, Wikler, A., Eddy, N., Wilson, J., & Moran, C: "Tolerance and addiction liability of 6-dimethylamino- 4,4-diphenyl-heptanone-3 (methadon)", _J.A.M.A_ 135:888, Dec 1947. [Carried out at the famous USPHS Hospital in Lexington, KY] "The original German designation of this drug is 10820 or 'amidon'; it is also known as 'amidone' and as 'Dolophine- Lilly'" The year is 1947. This is the government talking about a Lilly-trademarked product, "[s]ince the drug may soon come into clinical use" and they wished to "present an opinion on the liability of the drug to cause addiction." A couple of comments on Booth's remarks: You conveniently left out the part where he says "...whilst another [argument] states that it was later invented by a an American chemical company and derived from the Latin 'dolor,' meaning pain." In any case, Martin is just confused about the whole thing. He says it was "originally called dolophine hydrochloride". It was not. He says it was "developed in the Mallinckrodt Laboratories". Close. Mallinckrodt has been a major producer of methadone for many years, but the lab that was raided was I.G. Farben's. And he says that "Knowledge of the drug remained dormant until around 1970". Nope. Its ability to relieve pain was well- documented by the time it was released in 1947, and the JAMA article (2) even details its ability to substitute for and ameliorate withdrawal from morphine. Of course, Booth devotes about three sentences of a 300+ page book to this issue, so it was obviously not something he put a lot of effort into researching. Now, did Lilly actually derive the trademark name from 'dolor'? It's the most plausible explaination. But then this is the same company that came up with 'Prozac'. So who the hell knows. It's all in the minds of the marketing executives...who sure as hell aren't going to name a drug after Hitler. Not even the Germans did that... > And. What published source claims that LSD can be made > from Foster's Beer? The Anarchist's Cookbook, for one. [...]